diff --git a/configs/config-tfm.h b/configs/config-tfm.h
new file mode 100644
index 0000000..b8233e9
--- /dev/null
+++ b/configs/config-tfm.h
@@ -0,0 +1,52 @@
+/**
+ * \file config-tfm.h
+ *
+ * \brief TF-M medium profile, adapted to work on other platforms.
+ */
+/*
+ *  Copyright The Mbed TLS Contributors
+ *  SPDX-License-Identifier: Apache-2.0
+ *
+ *  Licensed under the Apache License, Version 2.0 (the "License"); you may
+ *  not use this file except in compliance with the License.
+ *  You may obtain a copy of the License at
+ *
+ *  http://www.apache.org/licenses/LICENSE-2.0
+ *
+ *  Unless required by applicable law or agreed to in writing, software
+ *  distributed under the License is distributed on an "AS IS" BASIS, WITHOUT
+ *  WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+ *  See the License for the specific language governing permissions and
+ *  limitations under the License.
+ */
+
+/* TF-M medium profile: mbedtls legacy configuration */
+#include "../configs/ext/tfm_mbedcrypto_config_profile_medium.h"
+
+/* TF-M medium profile: PSA crypto configuration */
+#define MBEDTLS_PSA_CRYPTO_CONFIG_FILE "../configs/ext/crypto_config_profile_medium.h"
+
+/***********************************************************/
+/* Tweak the configuration to remove dependencies on TF-M. */
+/***********************************************************/
+
+/* MBEDTLS_PSA_CRYPTO_SPM needs third-party files, so disable it. */
+#undef MBEDTLS_PSA_CRYPTO_SPM
+
+/* TF-M provides its own dummy implementations to save code size.
+ * We don't have any way to disable the tests that need these feature,
+ * so we just keep AES decryption enabled. We will resolve this through
+ * an official way to disable AES decryption, then this deviation
+ * will no longer be needed:
+ * https://github.com/Mbed-TLS/mbedtls/issues/7368
+ */
+#undef MBEDTLS_AES_SETKEY_DEC_ALT
+#undef MBEDTLS_AES_DECRYPT_ALT
+
+/* Use built-in platform entropy functions (TF-M provides its own). */
+#undef MBEDTLS_NO_PLATFORM_ENTROPY
+
+/* Disable buffer-based memory allocator. This isn't strictly required,
+ * but using the native allocator is faster and works better with
+ * memory management analysis frameworks such as ASan. */
+#undef MBEDTLS_MEMORY_BUFFER_ALLOC_C
diff --git a/configs/crypto_config_profile_medium.h b/configs/ext/crypto_config_profile_medium.h
similarity index 100%
rename from configs/crypto_config_profile_medium.h
rename to configs/ext/crypto_config_profile_medium.h
diff --git a/configs/tfm_mbedcrypto_config_profile_medium.h b/configs/ext/tfm_mbedcrypto_config_profile_medium.h
similarity index 100%
rename from configs/tfm_mbedcrypto_config_profile_medium.h
rename to configs/ext/tfm_mbedcrypto_config_profile_medium.h
diff --git a/include/mbedtls/check_config.h b/include/mbedtls/check_config.h
index 2e3ffc2..5651e71 100644
--- a/include/mbedtls/check_config.h
+++ b/include/mbedtls/check_config.h
@@ -205,6 +205,15 @@
 #error "MBEDTLS_ECDSA_C defined, but not all prerequisites"
 #endif
 
+#if defined(MBEDTLS_PK_C) && defined(MBEDTLS_USE_PSA_CRYPTO)
+#if defined(MBEDTLS_PK_CAN_ECDSA_SIGN) && !defined(MBEDTLS_ASN1_WRITE_C)
+#error "MBEDTLS_PK_C with MBEDTLS_USE_PSA_CRYPTO needs MBEDTLS_ASN1_WRITE_C for ECDSA signature"
+#endif
+#if defined(MBEDTLS_PK_CAN_ECDSA_VERIFY) && !defined(MBEDTLS_ASN1_PARSE_C)
+#error "MBEDTLS_PK_C with MBEDTLS_USE_PSA_CRYPTO needs MBEDTLS_ASN1_PARSE_C for ECDSA verification"
+#endif
+#endif /* MBEDTLS_PK_C && MBEDTLS_USE_PSA_CRYPTO */
+
 #if defined(MBEDTLS_ECJPAKE_C) &&           \
     ( !defined(MBEDTLS_ECP_C) ||            \
       !( defined(MBEDTLS_MD_C) || defined(MBEDTLS_PSA_CRYPTO_C) ) )
diff --git a/scripts/code_size_compare.py b/scripts/code_size_compare.py
index e764e9d..50836b3 100755
--- a/scripts/code_size_compare.py
+++ b/scripts/code_size_compare.py
@@ -156,8 +156,8 @@
         print("Unknown host architecture, cannot auto-detect arch.")
         sys.exit(1)
 
-TFM_MEDIUM_CONFIG_H = 'configs/tfm_mbedcrypto_config_profile_medium.h'
-TFM_MEDIUM_CRYPTO_CONFIG_H = 'configs/crypto_config_profile_medium.h'
+TFM_MEDIUM_CONFIG_H = 'configs/ext/tfm_mbedcrypto_config_profile_medium.h'
+TFM_MEDIUM_CRYPTO_CONFIG_H = 'configs/ext/crypto_config_profile_medium.h'
 
 CONFIG_H = 'include/mbedtls/mbedtls_config.h'
 CRYPTO_CONFIG_H = 'include/psa/crypto_config.h'
diff --git a/tests/scripts/all.sh b/tests/scripts/all.sh
index 9290aa6..ef84fe7 100755
--- a/tests/scripts/all.sh
+++ b/tests/scripts/all.sh
@@ -3095,49 +3095,29 @@
 # - component_test_tfm_config()
 common_tfm_config () {
     # Enable TF-M config
-    cp configs/tfm_mbedcrypto_config_profile_medium.h "$CONFIG_H"
-    cp configs/crypto_config_profile_medium.h "$CRYPTO_CONFIG_H"
+    cp configs/config-tfm.h "$CONFIG_H"
+    echo "#undef MBEDTLS_PSA_CRYPTO_CONFIG_FILE" >> "$CONFIG_H"
+    cp configs/ext/crypto_config_profile_medium.h "$CRYPTO_CONFIG_H"
 
-    # Adjust for the fact that we're building outside the TF-M environment.
-    #
-    # TF-M has separation, our build doesn't
-    scripts/config.py unset MBEDTLS_PSA_CRYPTO_SPM
-    scripts/config.py unset MBEDTLS_PSA_CRYPTO_KEY_ID_ENCODES_OWNER
-    # TF-M provdes its own (dummy) implemenation, from their tree
-    scripts/config.py unset MBEDTLS_AES_DECRYPT_ALT
-    scripts/config.py unset MBEDTLS_AES_SETKEY_DEC_ALT
-    # We have an OS that provides entropy, use it
-    scripts/config.py unset MBEDTLS_NO_PLATFORM_ENTROPY
-
-    # Other config adjustments to make the tests pass.
-    # Those should probably be adopted upstream.
+    # Other config adjustment to make the tests pass.
+    # This should probably be adopted upstream.
     #
     # - USE_PSA_CRYPTO for PK_HAVE_ECC_KEYS
     echo "#define MBEDTLS_USE_PSA_CRYPTO" >> "$CONFIG_H"
-    # pkparse.c and pkwrite.c fail to link without this
-    echo "#define MBEDTLS_OID_C" >> "$CONFIG_H"
-    # - ASN1_[PARSE/WRITE]_C found by check_config.h for pkparse/pkwrite
-    echo "#define MBEDTLS_ASN1_PARSE_C" >> "$CONFIG_H"
-    echo "#define MBEDTLS_ASN1_WRITE_C" >> "$CONFIG_H"
-    # - MD_C for HKDF_C
-    echo "#define MBEDTLS_MD_C" >> "$CONFIG_H"
 
-    # Config adjustments for better test coverage in our environment.
-    # These are not needed just to build and pass tests.
+    # Config adjustment for better test coverage in our environment.
+    # This is not needed just to build and pass tests.
     #
     # Enable filesystem I/O for the benefit of PK parse/write tests.
     echo "#define MBEDTLS_FS_IO" >> "$CONFIG_H"
-    # Disable this for maximal ASan efficiency
-    scripts/config.py unset MBEDTLS_MEMORY_BUFFER_ALLOC_C
 
     # Config adjustments for features that are not supported
     # when using only drivers / by p256-m
     #
-    # Disable all the features that auto-enable ECP_LIGHT (see build_info.h)
+    # Disable all the features that auto-enable ECP_LIGHT (see config_adjust_legacy_crypto.h)
     scripts/config.py -f "$CRYPTO_CONFIG_H" unset PSA_WANT_KEY_TYPE_ECC_KEY_PAIR_DERIVE
     # Disable deterministic ECDSA as p256-m only does randomized
     scripts/config.py -f "$CRYPTO_CONFIG_H" unset PSA_WANT_ALG_DETERMINISTIC_ECDSA
-
 }
 
 # Keep this in sync with component_test_tfm_config() as they are both meant
@@ -3898,8 +3878,8 @@
 
 component_build_tfm_armcc() {
     # test the TF-M configuration can build cleanly with various warning flags enabled
-    cp configs/tfm_mbedcrypto_config_profile_medium.h "$CONFIG_H"
-    cp configs/crypto_config_profile_medium.h "$CRYPTO_CONFIG_H"
+    cp configs/ext/tfm_mbedcrypto_config_profile_medium.h "$CONFIG_H"
+    cp configs/ext/crypto_config_profile_medium.h "$CRYPTO_CONFIG_H"
 
     msg "build: TF-M config, armclang armv7-m thumb2"
     make clean
@@ -3907,9 +3887,13 @@
 }
 
 component_build_tfm() {
-    # test the TF-M configuration can build cleanly with various warning flags enabled
-    cp configs/tfm_mbedcrypto_config_profile_medium.h "$CONFIG_H"
-    cp configs/crypto_config_profile_medium.h "$CRYPTO_CONFIG_H"
+    # Check that the TF-M configuration can build cleanly with various
+    # warning flags enabled. We don't build or run tests, since the
+    # TF-M configuration needs a TF-M platform. A tweaked version of
+    # the configuration that works on mainstream platforms is in
+    # configs/config-tfm.h, tested via test-ref-configs.pl.
+    cp configs/ext/tfm_mbedcrypto_config_profile_medium.h "$CONFIG_H"
+    cp configs/ext/crypto_config_profile_medium.h "$CRYPTO_CONFIG_H"
 
     msg "build: TF-M config, clang, armv7-m thumb2"
     make lib CC="clang" CFLAGS="--target=arm-linux-gnueabihf -march=armv7-m -mthumb -Os -std=c99 -Werror -Wall -Wextra -Wwrite-strings -Wpointer-arith -Wimplicit-fallthrough -Wshadow -Wvla -Wformat=2 -Wno-format-nonliteral -Wshadow -Wasm-operand-widths -Wunused -I../tests/include/spe"
diff --git a/tests/scripts/analyze_outcomes.py b/tests/scripts/analyze_outcomes.py
index 9254331..d15bb0b 100755
--- a/tests/scripts/analyze_outcomes.py
+++ b/tests/scripts/analyze_outcomes.py
@@ -552,6 +552,8 @@
             'ignored_suites': [
                 # Ignore test suites for the modules that are disabled in the
                 # accelerated test case.
+                'asn1parse',
+                'asn1write',
                 'ecp',
                 'ecdsa',
                 'ecdh',
@@ -615,28 +617,6 @@
                 'test_suite_psa_crypto_pake': [
                     'PSA PAKE: ecjpake size macros',
                 ],
-                'test_suite_asn1parse': [
-                    # This test depends on BIGNUM_C
-                    'INTEGER too large for mpi',
-                ],
-                'test_suite_asn1write': [
-                    # Following tests depends on BIGNUM_C
-                    'ASN.1 Write mpi 0 (1 limb)',
-                    'ASN.1 Write mpi 0 (null)',
-                    'ASN.1 Write mpi 0x100',
-                    'ASN.1 Write mpi 0x7f',
-                    'ASN.1 Write mpi 0x7f with leading 0 limb',
-                    'ASN.1 Write mpi 0x80',
-                    'ASN.1 Write mpi 0x80 with leading 0 limb',
-                    'ASN.1 Write mpi 0xff',
-                    'ASN.1 Write mpi 1',
-                    'ASN.1 Write mpi, 127*8 bits',
-                    'ASN.1 Write mpi, 127*8+1 bits',
-                    'ASN.1 Write mpi, 127*8-1 bits',
-                    'ASN.1 Write mpi, 255*8 bits',
-                    'ASN.1 Write mpi, 255*8-1 bits',
-                    'ASN.1 Write mpi, 256*8-1 bits',
-                ],
             }
         }
     }
diff --git a/tests/scripts/test-ref-configs.pl b/tests/scripts/test-ref-configs.pl
index 15209b4..80aa87a 100755
--- a/tests/scripts/test-ref-configs.pl
+++ b/tests/scripts/test-ref-configs.pl
@@ -49,6 +49,9 @@
     'config-symmetric-only.h' => {
         'test_again_with_use_psa' => 0, # Uses PSA by default, no need to test it twice
     },
+    'config-tfm.h' => {
+        'test_again_with_use_psa' => 0, # Uses PSA by default, no need to test it twice
+    },
     'config-thread.h' => {
         'opt' => '-f ECJPAKE.*nolog',
         'test_again_with_use_psa' => 1,
diff --git a/tests/suites/test_suite_pk.function b/tests/suites/test_suite_pk.function
index 881429c..fa0b03b 100644
--- a/tests/suites/test_suite_pk.function
+++ b/tests/suites/test_suite_pk.function
@@ -24,6 +24,17 @@
 #define RSA_KEY_SIZE   MBEDTLS_RSA_GEN_KEY_MIN_BITS
 #define RSA_KEY_LEN   (MBEDTLS_RSA_GEN_KEY_MIN_BITS/8)
 
+/* MBEDTLS_TEST_PK_PSA_SIGN is enabled when:
+ * - The build has PK_[PARSE/WRITE]_C for RSA or ECDSA signature.
+ * - The build has built-in ECC and ECDSA signature.
+ */
+#if (defined(MBEDTLS_PK_PARSE_C) && defined(MBEDTLS_PK_WRITE_C) && \
+    ((defined(MBEDTLS_RSA_C) && defined(MBEDTLS_GENPRIME)) || \
+    defined(MBEDTLS_PK_CAN_ECDSA_SIGN))) || \
+    (defined(MBEDTLS_ECP_C) && defined(MBEDTLS_PK_CAN_ECDSA_SIGN))
+#define MBEDTLS_TEST_PK_PSA_SIGN
+#endif
+
 #if defined(MBEDTLS_PK_USE_PSA_EC_DATA)
 static int pk_genkey_ec(mbedtls_pk_context *pk, mbedtls_ecp_group_id grp_id)
 {
@@ -1274,7 +1285,7 @@
 }
 /* END_CASE */
 
-/* BEGIN_CASE depends_on:MBEDTLS_MD_CAN_SHA256:MBEDTLS_USE_PSA_CRYPTO */
+/* BEGIN_CASE depends_on:MBEDTLS_MD_CAN_SHA256:MBEDTLS_USE_PSA_CRYPTO:MBEDTLS_TEST_PK_PSA_SIGN */
 void pk_psa_sign(int parameter_arg,
                  int psa_type_arg, int expected_bits_arg)
 {
diff --git a/tests/suites/test_suite_psa_crypto_slot_management.function b/tests/suites/test_suite_psa_crypto_slot_management.function
index 5bd12eb..b4f2d23 100644
--- a/tests/suites/test_suite_psa_crypto_slot_management.function
+++ b/tests/suites/test_suite_psa_crypto_slot_management.function
@@ -142,7 +142,6 @@
 
 #if defined(MBEDTLS_PSA_CRYPTO_KEY_ID_ENCODES_OWNER)
     {
-        psa_key_handle_t handle;
         mbedtls_svc_key_id_t key_with_invalid_owner =
             mbedtls_svc_key_id_make(owner_id + 1,
                                     MBEDTLS_SVC_KEY_ID_GET_KEY_ID(key));
@@ -150,8 +149,8 @@
         TEST_ASSERT(mbedtls_key_owner_id_equal(
                         owner_id,
                         MBEDTLS_SVC_KEY_ID_GET_OWNER_ID(key)));
-        TEST_EQUAL(psa_open_key(key_with_invalid_owner, &handle),
-                   PSA_ERROR_DOES_NOT_EXIST);
+        TEST_EQUAL(psa_get_key_attributes(key_with_invalid_owner, &attributes),
+                   PSA_ERROR_INVALID_HANDLE);
     }
 #endif