The PSA API is now the only API for cryptographic primitives.
The X.509, PKCS7 and SSL always use PSA for cryptography, with a few exceptions documented in the PSA limitations document. (These limitations are mostly transparent unless you want to leverage PSA accelerator drivers.) This corresponds to the behavior of Mbed TLS 3.x when MBEDTLS_USE_PSA_CRYPTO is enabled. In effect, MBEDTLS_USE_PSA_CRYPTO is now always enabled.
psa_crypto_init() must be called before performing any cryptographic operation, including indirect requests such as parsing a key or certificate or starting a TLS handshake.
A few functions take different parameters to migrate them to the PSA API. See “Function prototype changes”.
Mbed TLS follows the configuration of TF-PSA-Crypto with respect to cryptographic mechanisms. They are now based on PSA_WANT_xxx macros instead of legacy configuration macros such as MBEDTLS_RSA_C, MBEDTLS_PKCS1_V15, etc. The configuration of X.509 and TLS is not directly affected by the configuration. However, applications and middleware that rely on these configuration symbols to know which cryptographic mechanisms to support will need to migrate to PSA_WANT_xxx macros. For more information, consult the PSA transition guide in TF-PSA-Crypto.