diff --git a/tests/scripts/depends.py b/tests/scripts/depends.py
index 5606403..7d10732 100755
--- a/tests/scripts/depends.py
+++ b/tests/scripts/depends.py
@@ -55,6 +55,7 @@
 # Add the Mbed TLS Python library directory to the module search path
 import scripts_path # pylint: disable=unused-import
 import config
+from mbedtls_framework import c_build_helper
 
 class Colors: # pylint: disable=too-few-public-methods
     """Minimalistic support for colored output.
@@ -166,6 +167,50 @@
                 return False
         return True
 
+    def _consistency_check(self):
+        '''Check if the testable option is consistent with the goal.
+
+        The purpose of this function to ensure that every option is set or unset according to
+        the settings.
+        '''
+        log_command(['consistency check'])
+        c_name = None
+        exe_name = None
+        header = '#include "mbedtls/build_info.h"\n'
+
+        # Generate a C error directive for each setting to test if it is active
+        for option, value in sorted(self.config_settings.items()):
+            header += '#if '
+            if value:
+                header += '!'
+            header += 'defined(' + option + ')\n'
+            header += '#error "' + option + '"\n'
+            header += '#endif\n'
+        include_path = ['include', 'tf-psa-crypto/include',
+                        'tf-psa-crypto/drivers/builtin/include']
+
+        try:
+            # Generate a C file, build and run it
+            c_file, c_name, exe_name = c_build_helper.create_c_file(self.name)
+            c_build_helper.generate_c_file(c_file, 'depends.py', header, lambda x: '')
+            c_file.close()
+            c_build_helper.compile_c_file(c_name, exe_name, include_path)
+
+            return True
+
+        except c_build_helper.CompileError as e:
+            # Read the command line output to find out which setting has been failed
+            failed = {m.group(1) for m in re.finditer('.*#error "(.*)"', e.message) if m}
+            log_line('Inconsistent config option(s):')
+            for option in sorted(failed):
+                log_line('  ' + option)
+
+            return False
+
+        finally:
+            c_build_helper.remove_file_if_exists(c_name)
+            c_build_helper.remove_file_if_exists(exe_name)
+
     def test(self, options):
         '''Run the job's build and test commands.
 Return True if all the commands succeed and False otherwise.
@@ -173,6 +218,8 @@
 run all the commands, except that if the first command fails, none of the
 other commands are run (typically, the first command is a build command
 and subsequent commands are tests that cannot run if the build failed).'''
+        if not self._consistency_check():
+            return False
         built = False
         success = True
         for command in self.commands: