diff --git a/include/mbedtls/ssl.h b/include/mbedtls/ssl.h
index 2594964..29ba85a 100644
--- a/include/mbedtls/ssl.h
+++ b/include/mbedtls/ssl.h
@@ -1869,6 +1869,10 @@
  *                 Calling mbedtls_ssl_setup again is not supported, even
  *                 if no session is active.
  *
+ * \note           If #MBEDTLS_USE_PSA_CRYPTO is enabled, the PSA crypto
+ *                 subsystem must have been initialized by calling
+ *                 psa_crypto_init() before calling this function.
+ *
  * \param ssl      SSL context
  * \param conf     SSL configuration to use
  *