diff --git a/include/mbedtls/check_config.h b/include/mbedtls/check_config.h
index 41c3f24..620aff9 100644
--- a/include/mbedtls/check_config.h
+++ b/include/mbedtls/check_config.h
@@ -492,6 +492,10 @@
 #error "MBEDTLS_PSA_CRYPTO_C defined, but not all prerequisites"
 #endif
 
+#if defined(MBEDTLS_PSA_CRYPTO_SPM) && !defined(MBEDTLS_PSA_CRYPTO_C)
+#error "MBEDTLS_PSA_CRYPTO_SPM defined, but not all prerequisites"
+#endif
+
 #if defined(MBEDTLS_RSA_C) && ( !defined(MBEDTLS_BIGNUM_C) ||         \
     !defined(MBEDTLS_OID_C) )
 #error "MBEDTLS_RSA_C defined, but not all prerequisites"