diff --git a/configs/ext/crypto_config_profile_medium.h b/configs/ext/crypto_config_profile_medium.h
index af8869f..2871c94 100644
--- a/configs/ext/crypto_config_profile_medium.h
+++ b/configs/ext/crypto_config_profile_medium.h
@@ -125,6 +125,59 @@
 #define PSA_WANT_KEY_TYPE_ECC_KEY_PAIR_GENERATE 1
 //#define PSA_WANT_KEY_TYPE_ECC_KEY_PAIR_DERIVE   1
 
+/***********************************************************/
+/* Tweak the configuration to remove dependencies on TF-M. */
+/***********************************************************/
+
+/* MBEDTLS_PSA_CRYPTO_SPM needs third-party files, so disable it. */
+#undef MBEDTLS_PSA_CRYPTO_SPM
+
+/* Disable buffer-based memory allocator. This isn't strictly required,
+ * but using the native allocator is faster and works better with
+ * memory management analysis frameworks such as ASan. */
+#undef MBEDTLS_MEMORY_BUFFER_ALLOC_C
+
+// This macro is enabled in TFM Medium but is disabled here because it is
+// incompatible with baremetal builds in Mbed TLS.
+#undef MBEDTLS_PSA_CRYPTO_STORAGE_C
+
+// This macro is enabled in TFM Medium but is disabled here because it is
+// incompatible with baremetal builds in Mbed TLS.
+#undef MBEDTLS_ENTROPY_NV_SEED
+
+// These platform-related TF-M settings are not useful here.
+#undef MBEDTLS_PLATFORM_NO_STD_FUNCTIONS
+#undef MBEDTLS_PLATFORM_STD_MEM_HDR
+#undef MBEDTLS_PLATFORM_SNPRINTF_MACRO
+#undef MBEDTLS_PLATFORM_PRINTF_ALT
+#undef MBEDTLS_PLATFORM_STD_EXIT_SUCCESS
+#undef MBEDTLS_PLATFORM_STD_EXIT_FAILURE
+
+/*
+ * In order to get an example config that works cleanly out-of-the-box
+ * for both baremetal and non-baremetal builds, we detect baremetal builds
+ * (either IAR, Arm compiler or __ARM_EABI__ defined), and adjust some
+ * variables accordingly.
+ */
+#if defined(__IAR_SYSTEMS_ICC__) || defined(__ARMCC_VERSION) || defined(__ARM_EABI__)
+#define MBEDTLS_NO_PLATFORM_ENTROPY
+#else
+/* Use built-in platform entropy functions (TF-M provides its own). */
+#undef MBEDTLS_NO_PLATFORM_ENTROPY
+#endif
+
+/***********************************************************************
+ * Local changes to crypto config below this delimiter
+ **********************************************************************/
+
+// We expect TF-M to pick this up soon
+#define MBEDTLS_BLOCK_CIPHER_NO_DECRYPT
+
+/* CCM is the only cipher/AEAD enabled in TF-M configuration files, but it
+ * does not need CIPHER_C to be enabled, so we can disable it in order
+ * to reduce code size further. */
+#undef MBEDTLS_CIPHER_C
+
 #ifdef CRYPTO_HW_ACCELERATOR
 #include "crypto_accelerator_config.h"
 #endif