diff --git a/include/mbedtls/check_config.h b/include/mbedtls/check_config.h
index 7b7ecba..412bb0a 100644
--- a/include/mbedtls/check_config.h
+++ b/include/mbedtls/check_config.h
@@ -174,11 +174,6 @@
 #error "MBEDTLS_PKCS5_C defined, but not all prerequisites"
 #endif
 
-#if defined(MBEDTLS_PKCS1_V21) && \
-    !( defined(MBEDTLS_MD_C) || defined(MBEDTLS_PSA_CRYPTO_C) )
-#error "MBEDTLS_PKCS1_V21 defined, but not all prerequisites"
-#endif
-
 #if defined(MBEDTLS_ENTROPY_C) && (!defined(MBEDTLS_SHA512_C) &&      \
                                     !defined(MBEDTLS_SHA256_C))
 #error "MBEDTLS_ENTROPY_C defined, but not all prerequisites"
diff --git a/include/mbedtls/mbedtls_config.h b/include/mbedtls/mbedtls_config.h
index f460e0d..225664e 100644
--- a/include/mbedtls/mbedtls_config.h
+++ b/include/mbedtls/mbedtls_config.h
@@ -1180,15 +1180,10 @@
  *
  * Enable support for PKCS#1 v2.1 encoding.
  *
- * Requires: MBEDTLS_RSA_C and (MBEDTLS_MD_C or MBEDTLS_PSA_CRYPTO_C).
+ * Requires: MBEDTLS_RSA_C
  *
- * \warning If building without MBEDTLS_MD_C, you must call psa_crypto_init()
- * before doing any PKCS#1 v2.1 operation.
- *
- * \warning When building with MBEDTLS_MD_C, all hashes used with this
- * need to be available as built-ins (that is, for SHA-256, MBEDTLS_SHA256_C,
- * etc.) as opposed to just PSA drivers. So far, PSA drivers are only used by
- * this module in builds where MBEDTLS_MD_C is disabled.
+ * \warning If using a hash that is only provided by PSA drivers, you must
+ * call psa_crypto_init() before doing any PKCS#1 v2.1 operation.
  *
  * This enables support for RSAES-OAEP and RSASSA-PSS operations.
  */