diff --git a/docs/design_documents/rse.rst b/docs/design_documents/rse.rst
index 21e5fd4..d1a5b9e 100644
--- a/docs/design_documents/rse.rst
+++ b/docs/design_documents/rse.rst
@@ -25,9 +25,15 @@
 -----------------------
 
 The communication between RSE and other subsystems are primarily relying on the
-Message Handling Unit (MHU) module. The number of MHU interfaces between RSE
-and other cores is IMPDEF. Besides MHU other modules also could take part in
-the communication. RSE is capable of mapping the AP memory to its address space.
+Message Handling Unit (MHU) module.
+
+However, this is possible to use this communication protocol with a different
+mailbox than MHU, by setting the flag ``PLAT_MHU=NO_MHU`` and implementing the
+APIs given in the file: ``include/drivers/arm/rse_comms.h``.
+
+The number of MHU interfaces between RSE and other cores is IMPDEF. Besides MHU
+other modules also could take part in the communication. RSE is capable of
+mapping the AP memory to its address space.
 Thereby either RSE core itself or a DMA engine if it is present, can move the
 data between memory belonging to RSE or AP. In this way, a bigger amount of data
 can be transferred in a short time.
@@ -812,3 +818,4 @@
 
 *Copyright (c) 2023-2024, Arm Limited. All rights reserved.*
 *Copyright (c) 2024, Linaro Limited. All rights reserved.*
+*Copyright (c) 2025, STMicroelectronics - All Rights Reserved*
diff --git a/drivers/arm/rse/rse_comms.c b/drivers/arm/rse/rse_comms.c
index cfc5a83..cd84394 100644
--- a/drivers/arm/rse/rse_comms.c
+++ b/drivers/arm/rse/rse_comms.c
@@ -1,5 +1,5 @@
 /*
- * Copyright (c) 2022-2024, Arm Limited. All rights reserved.
+ * Copyright (c) 2022-2025, Arm Limited and Contributors. All rights reserved.
  *
  * SPDX-License-Identifier: BSD-3-Clause
  */
@@ -24,7 +24,7 @@
 static uint8_t select_protocol_version(const psa_invec *in_vec, size_t in_len,
 				       const psa_outvec *out_vec, size_t out_len)
 {
-	size_t comms_mhu_msg_size;
+	size_t comms_mbx_msg_size;
 	size_t comms_embed_msg_min_size;
 	size_t comms_embed_reply_min_size;
 	size_t in_size_total = 0;
@@ -38,7 +38,7 @@
 		out_size_total += out_vec[i].len;
 	}
 
-	comms_mhu_msg_size = mhu_get_max_message_size();
+	comms_mbx_msg_size = rse_mbx_get_max_message_size();
 
 	comms_embed_msg_min_size = sizeof(struct serialized_rse_comms_header_t) +
 				   sizeof(struct rse_embed_msg_t) -
@@ -49,9 +49,9 @@
 				     PLAT_RSE_COMMS_PAYLOAD_MAX_SIZE;
 
 	/* Use embed if we can pack into one message and reply, else use
-	 * pointer_access. The underlying MHU transport protocol uses a
+	 * pointer_access. The underlying mailbox transport protocol uses a
 	 * single uint32_t to track the length, so the amount of data that
-	 * can be in a message is 4 bytes less than mhu_get_max_message_size
+	 * can be in a message is 4 bytes less than rse_mbx_get_max_message_size
 	 * reports.
 	 *
 	 * TODO tune this with real performance numbers, it's possible a
@@ -60,9 +60,9 @@
 	 * pointers.
 	 */
 	if ((comms_embed_msg_min_size + in_size_total >
-	     comms_mhu_msg_size - sizeof(uint32_t)) ||
+	     comms_mbx_msg_size - sizeof(uint32_t)) ||
 	    (comms_embed_reply_min_size + out_size_total >
-	     comms_mhu_msg_size - sizeof(uint32_t))) {
+	     comms_mbx_msg_size - sizeof(uint32_t))) {
 		return RSE_COMMS_PROTOCOL_POINTER_ACCESS;
 	} else {
 		return RSE_COMMS_PROTOCOL_EMBED;
@@ -76,7 +76,7 @@
 	 * functions not being reentrant becomes a problem.
 	 */
 	static union rse_comms_io_buffer_t io_buf;
-	enum mhu_error_t err;
+	int err;
 	psa_status_t status;
 	static uint8_t seq_num = 1U;
 	size_t msg_size;
@@ -109,8 +109,8 @@
 		VERBOSE("in_vec[%lu].buf=%p\n", idx, (void *)in_vec[idx].base);
 	}
 
-	err = mhu_send_data((uint8_t *)&io_buf.msg, msg_size);
-	if (err != MHU_ERR_NONE) {
+	err = rse_mbx_send_data((uint8_t *)&io_buf.msg, msg_size);
+	if (err != 0) {
 		return PSA_ERROR_COMMUNICATION_FAILURE;
 	}
 
@@ -122,8 +122,8 @@
 	memset(&io_buf.msg, 0xA5, msg_size);
 #endif
 
-	err = mhu_receive_data((uint8_t *)&io_buf.reply, &reply_size);
-	if (err != MHU_ERR_NONE) {
+	err = rse_mbx_receive_data((uint8_t *)&io_buf.reply, &reply_size);
+	if (err != 0) {
 		return PSA_ERROR_COMMUNICATION_FAILURE;
 	}
 
@@ -144,7 +144,7 @@
 		VERBOSE("out_vec[%lu].buf=%p\n", idx, (void *)out_vec[idx].base);
 	}
 
-	/* Clear the MHU message buffer to remove assets from memory */
+	/* Clear the mailbox message buffer to remove assets from memory */
 	memset(&io_buf, 0x0, sizeof(io_buf));
 
 	seq_num++;
diff --git a/drivers/arm/rse/rse_comms.mk b/drivers/arm/rse/rse_comms.mk
index f26d2c5..743e978 100644
--- a/drivers/arm/rse/rse_comms.mk
+++ b/drivers/arm/rse/rse_comms.mk
@@ -16,6 +16,7 @@
 # Default to MHUv2 if PLAT_MHU undefined
 PLAT_MHU ?= MHUv2
 
+ifneq (${PLAT_MHU}, NO_MHU)
 ifeq (${PLAT_MHU}, MHUv3)
 RSE_COMMS_SOURCES	+=	$(addprefix drivers/arm/mhu/,			\
 					mhu_v3_x.c				\
@@ -30,6 +31,12 @@
 $(error Unsupported MHU version)
 endif
 
+RSE_COMMS_SOURCES	+=	$(addprefix drivers/arm/rse/,			\
+					rse_comms_mhu.c				\
+				)
+
+PLAT_INCLUDES		+=	-Idrivers/arm/mhu
+endif
+
 PLAT_INCLUDES		+=	-Idrivers/arm/rse		\
-				-Idrivers/arm/mhu		\
 				-Iinclude/lib/psa
diff --git a/drivers/arm/rse/rse_comms_mhu.c b/drivers/arm/rse/rse_comms_mhu.c
new file mode 100644
index 0000000..8032393
--- /dev/null
+++ b/drivers/arm/rse/rse_comms_mhu.c
@@ -0,0 +1,71 @@
+/*
+ * Copyright (c) 2025, Arm Limited and Contributors. All rights reserved.
+ *
+ * SPDX-License-Identifier: BSD-3-Clause
+ */
+
+#include <stdint.h>
+#include <string.h>
+
+#include <common/debug.h>
+#include <drivers/arm/mhu.h>
+#include <drivers/arm/rse_comms.h>
+
+size_t rse_mbx_get_max_message_size(void)
+{
+	return mhu_get_max_message_size();
+}
+
+int rse_mbx_send_data(const uint8_t *send_buffer, size_t size)
+{
+	enum mhu_error_t err = mhu_send_data(send_buffer, size);
+
+	if (err != MHU_ERR_NONE) {
+		ERROR("mhu_send_data err=%d\n", err);
+		return -1;
+	}
+
+	return 0;
+}
+
+int rse_mbx_receive_data(uint8_t *receive_buffer, size_t *size)
+{
+	enum mhu_error_t err = mhu_receive_data(receive_buffer, size);
+
+	if (err != MHU_ERR_NONE) {
+		ERROR("mhu_receive_data err=%d\n", err);
+		return -1;
+	}
+
+	return 0;
+}
+
+int rse_mbx_init(const void *init_data)
+{
+	enum mhu_error_t err;
+	const struct mhu_addr *mbx_addr = (const struct mhu_addr *)init_data;
+
+	err = mhu_init_sender(mbx_addr->sender_base);
+	if (err != MHU_ERR_NONE) {
+		if (err == MHU_ERR_ALREADY_INIT) {
+			INFO("[RSE-COMMS] Host to RSE MHU driver already initialized\n");
+		} else {
+			ERROR("[RSE-COMMS] Host to RSE MHU driver initialization failed: %d\n",
+			      err);
+			return -1;
+		}
+	}
+
+	err = mhu_init_receiver(mbx_addr->receiver_base);
+	if (err != MHU_ERR_NONE) {
+		if (err == MHU_ERR_ALREADY_INIT) {
+			INFO("[RSE-COMMS] RSE to Host MHU driver already initialized\n");
+		} else {
+			ERROR("[RSE-COMMS] RSE to Host MHU driver initialization failed: %d\n",
+			      err);
+			return -1;
+		}
+	}
+
+	return 0;
+}
diff --git a/include/drivers/arm/mhu.h b/include/drivers/arm/mhu.h
index 31c6a81..cc74e27 100644
--- a/include/drivers/arm/mhu.h
+++ b/include/drivers/arm/mhu.h
@@ -1,5 +1,6 @@
 /*
  * Copyright (c) 2022, Arm Limited. All rights reserved.
+ * Copyright (c) 2025, Arm Limited and Contributors. All rights reserved.
  *
  * SPDX-License-Identifier: BSD-3-Clause
  */
@@ -25,6 +26,14 @@
 };
 
 /**
+ * Structure used by RSE comms
+ */
+struct mhu_addr {
+	uintptr_t sender_base;
+	uintptr_t receiver_base;
+};
+
+/**
  * Initializes sender MHU.
  *
  * mhu_sender_base	Base address of sender MHU.
diff --git a/include/drivers/arm/rse_comms.h b/include/drivers/arm/rse_comms.h
index e4169a5..e390cce 100644
--- a/include/drivers/arm/rse_comms.h
+++ b/include/drivers/arm/rse_comms.h
@@ -1,5 +1,5 @@
 /*
- * Copyright (c) 2022, Arm Limited. All rights reserved.
+ * Copyright (c) 2022-2025, Arm Limited and Contributors. All rights reserved.
  *
  * SPDX-License-Identifier: BSD-3-Clause
  *
@@ -8,8 +8,13 @@
 #ifndef RSE_COMMS_H
 #define RSE_COMMS_H
 
+#include <stddef.h>
 #include <stdint.h>
 
+size_t rse_mbx_get_max_message_size(void);
+int rse_mbx_send_data(const uint8_t *send_buffer, size_t size);
+int rse_mbx_receive_data(uint8_t *receive_buffer, size_t *size);
+int rse_mbx_init(const void *init_data);
 int rse_comms_init(uintptr_t mhu_sender_base, uintptr_t mhu_receiver_base);
 
 #endif /* RSE_COMMS_H */